Inyección
Inyección
Nose‐to‐Brain Delivery of Circular RNA SCMH1‐Loaded Lipid Nanoparticles for Ischemic Stroke Therapy
27/03/2025 -
An efficient and safe circular‐RNA delivery system circSCMH1@LNP1 is developed for direct nose‐to‐brain delivery of circRNA SCMH1 to ischemic lesions. Experiments demonstrate that intranasally...
A General Strategy for Exceptionally Robust Conducting Polymer‐Based Bioelectrodes with Multimodal Capabilities Through Decoupled Charge Transport Mechanisms
12/03/2025 -
This work presents an effective strategy to address a longstanding challenge in the practical application of soft bioelectrodes: integrating excellent electrical performance, high compactness, and...
Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction
06/03/2025 -
The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These...
Nanoscale Biodegradable Printing for Designed Tuneability of Vaccine Delivery Kinetics
28/02/2025 -
Spatiotemporal Controlled Release Inks of Biocompatible polyEsters (SCRIBE) is a novel 2PP resin family with sub‐micron resolution and tuneable hydrolysis. SCRIBE enables direct printing of hollow...
Lab‐in‐Cell: A Covalent Photosensitizer Reverses Hypoxia and Evokes Ferroptosis and Pyroptosis for Enhanced Anti‐Tumor Immunity
23/02/2025 -
The covalent warhead alkynamide is incorporated into an aggregation‐induced emission photosensitizer, developing a redox systems‐targeting covalent photosensitizer MBTP‐PA. It is aimed at...
Generating Self‐Adjuvated Nanofiber Vaccines by Coating Bacterial Flagella with Antigens
21/02/2025 -
Coating bacterial flagella with antigens is used as a versatile platform for developing self‐adjuvated nanofiber vaccines. The resulting flagellum‐based subunit vaccines with appealing features...
DNA‐Capturing Manganese‐Coordinated Chitosan Microparticles Potentiate Radiotherapy via Activating the cGAS‐STING Pathway and Maintaining Tumor‐Infiltrating CD8+ T‐Cell Stemness
16/02/2025 -
DNA‐capturing CS‐Mn microparticles are prepared to potentiate radioimmunotherapy. Upon injection into the tumors after X‐ray irradiation, they undergo rapid dissociation to release chitosan...
Atomic Layer Deposition Stabilizes Nanocrystals, Enabling Reliably High‐Performance Quantum Dot LEDs
09/02/2025 -
Atomic layer deposition (ALD) of Al₂O₃ on ZnMgO nanocrystals eliminates aging‐induced performance variability in quantum dot light‐emitting diodes (QD‐LEDs). This scalable passivation...
NIR‐II Fluorescent Thermophoretic Nanomotors for Superficial Tumor Photothermal Therapy
02/02/2025 -
A spherical core‐shell nanomotor consisting of a polydopamine‐indocyanine green composite shell and a rigid functional core is proposed in this work. This motor can be activated by the NIR‐I...
Metalloparticle‐Engineered Pickering Emulsion Displaying AAV‐Vectored Vaccine for Enhancing Antigen Expression and Immunogenicity Against Pathogens
19/01/2025 -
Pickering emulsion is stabilized by biomineralized manganese nanoparticles and aluminum hydroxide, enabling rapid and efficient loading of AAVs, diversifying AAV endocytic pathways, and further...
Nicotine Ameliorates α-Synuclein Preformed Fibril-Induced Behavioral Deficits and Pathological Features in Mice
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Abstract Epidemiologic study suggests that nicotine reduces the risk of Parkinsonâs disease (PD) and thus could serve as a potential treatment. In this study, we aimed to...
WTAP Promotes Atherosclerosis by Inducing Macrophage Pyroptosis and M1 Polarization through Upregulating NLRP3
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Abstract The study was designed to investigate the impact of N6-methyladenosine (m6A) writer Wilms tumor 1-associated protein (WTAP) on the progression of atherosclerosis (AS) and...
Ionic Diode‐Based Drug Delivery System
24/12/2024 -
An ionic diode‐based drug delivery system is demonstrated, which uses electric potential for spatiotemporally controlled yet sustained drug release with minimal leakage. It provides flow‐free...
Rationally Engineering Pro‐Proteins and Membrane‐Penetrating α‑Helical Polypeptides for Genome Editing Toward Choroidal Neovascularization Treatment
24/12/2024 -
Adenosine triphosphate‐tagged pro‐proteins are engineered to form stable nanocomplexes with guanidyl‐rich, α‐helical polypeptide and enable robust cytosolic delivery. By delivering...
Adaptive In‐Sensor Computing for Enhanced Feature Perception and Broadband Image Restoration
10/12/2024 -
A novel phototransistor is introduced by leveraging the unique optoelectronic properties of two low‐dimensional materials. The architecture enhances image perception and restoration quality,...
High‐Performance Green and Blue Light‐Emitting Diodes Enabled by CdZnSe/ZnS Core/Shell Colloidal Quantum Wells
09/12/2024 -
A new synthesis strategy for CdZnSe/ZnS core/shell colloidal quantum wells, which covers the green and blue spectral range and exhibits exceptional photoelectric properties, is achieved by direct...
Clickable, Thermally Responsive Hydrogels Enabled by Recombinant Spider Silk Protein and Spy Chemistry for Sustained Neurotrophin Delivery
08/12/2024 -
An injectable hydrogel comprising recombinant spider silk proteins is formed through ultrasound and thermally induced phase transition. Thanks to SpyTag/SpyCatcher chemistry, neurotrophins such as...
Si‐H Hydrosilane Reducing Agents for Size‐ and Shape‐Controlled InAs Colloidal Quantum Dots
04/12/2024 -
This study introduces a novel mild reducing agent that successfully produces large, uniform InAs colloidal quantum dots (CQDs) with excellent optoelectronic properties. The elimination of (TMS)3As in...
Controlling Ion Uptake in Carboxylated Mixed Conductors
04/12/2024 -
A series of p‐channel carboxylated mixed conductors is investigated to advance understanding and design strategies toward next‐generation OMIEC systems. Varying side‐chain functionality,...
Rheological and UV?Protecting Properties of Biobased and Biodegradable Blends for Injection Molding Applications
20/11/2024 -
Microwave?assisted–based metformin hydrogel is developed and evaluated.Microwave?assisted hydrogel played major role in wound healing effect of drug.Microwave?assisted hydrogel containing locust...
Simulation and Experimental Study on Enhancing Dimensional Accuracy of Polycarbonate Light Guides
19/11/2024 -
This research investigates the adaptation of conventional injection-molding techniques for producing thick-walled polycarbonate optical components, specifically targeting their application in...
